The Essencial Project (EP) is a public policy initiative that was implemented in 2015, in primary care centres of Catalonia. The EP is based on knowledge transfer, evidence-based practices to avoid unnecessary care by the elaboration of recommendations to reduce low value clinical practices (LVCPs), such as overdiagnosis, overtreatment, overuse. EP includes four phases: 1) identification of LVCPs from HCPs, identification of clinical leaders in the primary care teams 2) prioritisation and elaboration of recommendations, 3) implementation of recommendations and impact assessment, feedback to monthly primary care teams using electronic health records and 4) communication of the products adapted to the citizens and patients. In total, 169 primary care teams participated. The impact of this practice demonstrated a reduction in LVCP, including a 33% reduction in prostatespecific antigen screening and 44% reduction in statin prescriptions for cardiovascular disease prevention. Out of 86 recommendations for primary care, 25 were implemented. A survey identified that 69% of the HCPs believe that they are best positioned to deal with LVCPs. Also 64% of HCPs need to decide based on LVCP more than once per week. The lessons learnt from this project include: 1) the importance of considering local context for the de-adoption of strategies, 2) providing adequate training and communication material for patients and clinicians, 3) supporting key role of clinical leaders from providers 4) addressing barriers identified needs a multidisciplinary approach and broad stakeholder commitment.